After preventing a terrorist attack at a refugee camp in Greece, Wonder Woman returned to a government facility in the United States and was examined by a sickly doctor, Dr. Shannon Crawford. That evening, Diana attended the wedding of Etta Candy's brother, where she discovered a bomb seconds away from detonation hidden underneath one of the tables. She was able to contain the blast, but Etta was injured by a piece of shrapnel. She returned Etta to Dr. Crawford who removed the shrapnel, before touching Wonder Woman with an Amazon-strength sedative she had developed, leaving Diana too weak to fight back. Dr. Crawford told Diana that she had a rare genetic illness, and that she intended to use Diana's Amazon blood to develop a cure, saving her life as well as providing life-saving treatment for others afflicted with the same disease. Diana awoke to discover Crawford had developed Amazonian strength as a result of the blood transfusion. She was able to bind Dr. Crawford in the Lasso of Truth, which rejected the lie and restored Crawford to her previous state. Having lost hope for a cure, Crawford injected herself with the sedative, killing her. Wonder Woman was too late to stop her, but she understood Crawford's decision to end her pain and held her as she died.
Starting in Wonder Woman vol. 2 #51, the Amazons, who had revealed their presence to the world in Wonder Woman vol. 2 #50, are blamed for a series of murders and for the theft of various artifacts. The Amazons are then taken into custody, Queen Hippolyta is nowhere to be found and Steve Trevor is forced by General Yedziniak to attack Themyscira. These events lead to the "War of the Gods" occurring. The culprit of the murders, thefts and the framing of the Amazons is revealed to be the witch Circe, who "kills" Diana by reverting her form back into the clay she was born from. Later, Wonder Woman is brought back to life and together with Donna Troy, battles Circe and ultimately defeats her. Circe would later return by unknown means.
Impressed by this unknown woman's self-sacrifice, the Amazons entombed her with honors and clothed her in armor displaying the American flag pattern on her uniform, which they assumed were her heraldic colors. Trevor's legacy was also the primary reason why Ares arranged for Steve Trevor to bomb the island, as he could not resist the irony of the heroine's son unwittingly killing her admirers.